xViTCOS: Explainable Vision Transformer Based COVID-19 Screening Using RadiographyxViTCOS: 방사선 사진을 사용한 설명 가능한 비전 변환기 기반 COVID-19 스크리닝Article Published on 2022-12-082022-09-10 Journal: IEEE Journal of Translational Engineering in Healt [Category] SARS, 치료기술, [키워드] AI for COVID-19 detection capture Care Chest radiography CNN code collapse country COVID-19 COVID-19 positive patient COVID-19 positive patients CT scan and CXR deep deep learning demonstrated diagnosis of COVID-19 feature globe Health Health care Health care system Healthcare system help identify imperative implementation inherent issue learning Localization outbreak outperform Radiography Radiologists reduce Region researcher resources RT-PCR Screening screening test Spread the disease transfer transformer verge Virus Disease vision vision transformer X-ray [DOI] 10.1109/JTEHM.2021.3134096 PMC 바로가기 [Article Type] Article
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue LocalizationArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] Act adaptive adaptive immunity against SARS-CoV-2 antibody COVID-19 elicited Immunity Infection Kinetics Lineage Localization new SARS-CoV-2 Primary infection PROTECT Protein reduced right SARS-CoV-2 Spike-specific antibody Spread T cell T cell response T cells the Spike tissue-resident T cells. vaccinated individual vaccination viral replication Wuhan isolate [DOI] 10.3390/ijms231810679 PMC 바로가기
Expression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected CellsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome analyzed antibody antiviral strategy caused coronavirus COVID-19 pandemic determine diagnosis of SARS-CoV-2 diagnostics different time points diffusion dsRNA expression expression profile foci function Gene Expression immunofluorescence assay indicated Infection Localization mechanism mechanisms N protein nonstructural protein nsp13 nsp14 Nsp15 NSP2 Nsp3 Nsp9 Postinfection potential molecular profile Protein protein-protein interaction Proteins provide regulated replicase replicase proteins Replication responsible SARS-CoV-2 SARS-CoV-2-infected cell subcellular distribution subcellular localization subcellular localization. suggested viral growth virus replication [DOI] 10.1128/spectrum.00744-22 PMC 바로가기
Coronavirus disease 2019 and the placenta: A literature review코로나바이러스 질병 2019 및 태반: 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis single-cell analysis. the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus [DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review
Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19혈소판 활성화 및 부분 탈감작은 중증 COVID-19 환자의 바이러스 이종과 관련이 있습니다Article Published on 2022-07-122022-09-11 Journal: Blood advances [Category] COVID19(2023년), SARS, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Alter assays autophagy Bacterial sepsis changes in Combination Complication coronavirus Critically ill critically ill patients Cytokines decrease develop exhibited flow cytometry fraction Gene Expression GPVI healthy healthy donor healthy donors immunofluorescence indicated infected patient infected patients intensive care intensive care unit interactions intracellular vesicle investigated labeling leukocyte Localization lung marker mass spectrometry Microscopy Nucleocapsid proteins parameter Patient patients with COVID-19 plasma Platelet platelet activation platelet aggregation platelet-rich thrombi Platelets Proinflammatory cytokine proinflammatory cytokines prospective cohort Protein reduction SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles secretion selective Sepsis severe acute respiratory syndrome Coronavirus severe COVID-19 shown spike Stimulation Structure Tandem mass spectrometry These data thrombi thrombocytopenia transmission electron microscopy Xenophagy [DOI] 10.1182/bloodadvances.2022007143 PMC 바로가기 [Article Type] Article
Characterization of the Interaction Between SARS-CoV-2 Membrane Protein (M) and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target잠재적 치료 표적으로서 SARS-COV-2 막 단백질 (M)과 증식 세포 핵 항원 (PCNA) 사이의 상호 작용의 특성화Article Published on 2022-05-232022-08-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] addition association Cell characterization Coronaviridae family COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 therapy cytoplasm DNA DNA damage DNA replication expression function immunofluorescence immunohistochemistry immunoprecipitation in vitro increase in infected with SARS-CoV-2 Interaction ligation Localization lung M protein marker membrane protein nucleus PCNA Potential reduction repair reported responsible SARS-CoV-2 target the Coronaviridae therapy transfected with translocation Transport Verdinexor viral-host interaction viral-host interaction. virion virus [DOI] 10.3389/fcimb.2022.849017 PMC 바로가기 [Article Type] Article
Human-to-dog transmission of SARS-CoV-2, Colombia콜롬비아, SARS-CoV-2의 사람에서 개 전염Article Published on 2022-05-122022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 protein acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 causative agent clade close contact Complete conservation contribute coronavirus 2 COVID-19 pandemic docking E484K E484K mutation events Genome help hosts Human Latin America Lineage Localization molecular analysis Mutation non-human primates Phylogenetic prediction Prevent Protein protein structure public health RBD receptor Receptor-binding domain respiratory SARS-CoV-2 sequenced Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein symptomatic the receptor-binding domain the Spike Transmission transmission of SARS-CoV-2 viral infection viral sequence viral sequences virus [DOI] 10.1038/s41598-022-11847-9 PMC 바로가기 [Article Type] Article
Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screenCRISPR/Cas9 화면을 통한 SARS-CoV-2의 제한 요인으로 DAXX 식별Article Published on 2022-05-042022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antiviral activity basal Cell culture CRISPR cytoplasmic DAXX Degradation dependent on DNA virus DNA viruses domain expression Factors functional human cells identification identify independent independent of Infection inhibitor interferon life cycle limit Localization mechanism nuclear over-expression Papain-like protease pathway PLPro PML promote proteasome Protein Replication replication of SARS-CoV-2 restrict restriction factor retroviruses SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle SARS-CoV-2 replication scaffold protein the SARS-CoV-2 Trigger turn [DOI] 10.1038/s41467-022-30134-9 PMC 바로가기 [Article Type] Article
In vivo imaging of invasive aspergillosis with 18 F-fluorodeoxysorbitol positron emission tomography18 F-플루오로데옥시소르비톨 양전자 방출 단층 촬영을 사용한 침습성 아스페르길루스증의 생체 내 영상화Article Published on 2022-04-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] aspergillosis Aspergillus Aspergillus fumigatus Brain can be used caused clinical information clinical outcomes Combination Critical detect Diagnosis Diagnostic method differential diagnosis Hematologic malignancy Immunocompromised patient Immunocompromised patients induce Infection infections Influenza Influenza virus invasive Localization Lungs Mouse models muscle muscles pet Pneumonia positron emission Positron emission tomography pulmonary aspergillosis pulmonary infiltrate pulmonary infiltrates Staphylococcus aureus time-consuming tomography Viral Viral pneumonia [DOI] 10.1038/s41467-022-29553-5 PMC 바로가기 [Article Type] Article